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  • Title: Inoculated mouse model of Pneumocystis carinii pneumonia.
    Author: Bartlett MS, Queener SF, Durkin MM, Shaw MM, Smith JW.
    Journal: J Protozool; 1991; 38(6):130S-131S. PubMed ID: 1818136.
    Abstract:
    A transtracheally inoculated mouse model of Pneumocystis carinii has been developed using BALB/c mice, a widely available strain free of latent P. carinii infection. The mean infectivity score of untreated inoculated mice was 4.1 compared to the mean infectivity score of 0.1 for trimethoprim/sulfamethoxazole (50/250 mg/kg) treated inoculated mice, approximately a four-log difference. An inoculated mouse model of P. carinii infection provides both a source of organisms from a different host and an animal model for study of drugs for therapy and prophylaxis which is less costly than rats and which requires less drug than required for rats.
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