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  • Title: [Changes of prethrombotic state indexes in patients with malignant cancer].
    Author: Abudoureyimu S, Zhang HL, Aizezi R, Jin W, Upur H.
    Journal: Zhong Nan Da Xue Xue Bao Yi Xue Ban; 2007 Dec; 32(6):973-7. PubMed ID: 18182712.
    Abstract:
    OBJECTIVE: To study the changes and significance of prethrombotic state indexes in patients with malignant cancer. METHODS: The expression of CD62p on platelets, level of plasma tissue plasminogen activator (t-PA), level of serum endothelin (ET-1), activated partial thromboplastin time (APTT), fibrinogen ( FIB), prothrombin time (PT), and thrombin time (TT) were examined by flow cytometer, enzyme-linked immunosorbent assay, radioimmunoassay method, and auto coagulometer. RESULTS: The average expression of CD62P, level of plasma FIB and serum ET-1 in the tumor group increased compared with those in the control group (P<0.05); the level of t-PA in the tumor group decreased compared with that in the control group (P<0.05). APTT and PT were significantly shortened in the tumor group (P<0.05). There was no significant changes of TT in 2 groups (P>0.05). CONCLUSION: The platelet is activated, the thrombin activity increases, and the fibrinolytic function declines in patients with malignant cancer; there is an obvious prethrombotic state in patients with malignant cancer.
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