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  • Title: Primary hepatic clear cell myomelanocytic tumor. Case report and review of the literature.
    Author: Larbcharoensub N, Karnsombut P, Jatchavala J, Wasutit Y, Nitiyanant P.
    Journal: APMIS; 2007 Dec; 115(12):1454-9. PubMed ID: 18184420.
    Abstract:
    A case of hepatic clear cell myomelanocytic tumor in a 31-year-old woman presenting clinically with abdominal pain is reported. Histopathologic examination showed a lesion characterized by a population of large epithelioid cells with clear or eosinophilic granular cytoplasm, rich in glycogen. Immunohistochemically, the tumor cells were positive for HMB-45, Melan-A and muscle-specific actin, but negative for epithelial markers, desmin, S-100 protein, and neuroendocrine markers. Ultrastructurally, the tumor cells had abundant glycogen, well-developed rough endoplasmic reticulum, microtubules and aberrant melanosomes. Clinical and pathologic features with a brief review of the relevant literature for hepatic CCMMT as a variant of perivascular epithelioid cell tumor (PEComa) are discussed.
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