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  • Title: New horizons in the pathogenesis of gastrointestinal neuromuscular disease.
    Author: Knowles CH.
    Journal: J Pediatr Gastroenterol Nutr; 2007 Dec; 45 Suppl 2():S97-102. PubMed ID: 18185077.
    Abstract:
    The term "gastrointestinal neuromuscular disease" can be interpreted variably and encompasses a spectrum of paediatric and adult conditions including achalasia, pseudoobstruction, idiopathic constipation, irritable bowel syndrome, megacolon, and Hirschsprung disease. Although progress has been made in the understanding of the pathophysiology of some conditions, the aetiopathogenesis has been elucidated only in the rare minority. This review critically considers the available evidence for possible pathogenic mechanisms in these disorders.
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