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  • Title: Synthesis and cytotoxicity of platinum(II) complexes of a physiologically active carrier histamine.
    Author: Chen XZ, Ye QS, Lou LG, Xie MJ, Liu WP, Yu Y, Hou SQ.
    Journal: Arch Pharm (Weinheim); 2008 Feb; 341(2):132-6. PubMed ID: 18186542.
    Abstract:
    A series of novel platinum(II) complexes involving a physiologically active carrier histamine as the carrier, cis-[Pt(histamine)X2] (X2=2Cl-, oxalate, malonate, 1,1-cyclobutanedicarboxylate (CBDCA), 3-hydroxy-1,1-cyclobutanedicarboxylate (HO-CBDCA)), have been synthesized and characterized by elemental analysis and spectroscopic data along with X-ray crystal structure for a representative complex cis-[Pt(histamine)Cl2]. The cytotoxicity of the complexes has also been assessed in the human cancer cell lines A549/ATCC, HT-29, and LNcap. One complex, cis-[Pt(histamine)Cl2], is more active than carboplatin against both the sensitive and resistant cells.
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