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  • Title: Effect of nafoxidine (U-11,100A) on the induction of uterine peroxidase.
    Author: McNabb T, Jellinck PH.
    Journal: Steroids; 1976 May; 27(5):681-9. PubMed ID: 181872.
    Abstract:
    The relationship between the quantity of nuclear estrogen receptor complex formed and the amount of peroxidase induced by estradiol in immature rat uteri was determined. A good correlation was obtained between the quantity of 3H-estradiol specifically bound to the nuclear pellet and the amount of enzyme present 12 h after treatment with physiological doses of estrogen. Nafoxidine (U-11,100A) administered together with estrogen reduced signficantly the increase in peroxidase activity brought about by estradiol. Pretreatment with nafoxidine was less effective. The possible mechanism of action of this antiestrogen is discussed.
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