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  • Title: Extensive brainstem ischemia on neuroimaging does not preclude meaningful recovery from locked-in syndrome: two cases of endovascularly managed basilar thrombosis.
    Author: Tomycz ND, Holm MB, Horowitz MB, Wechsler LR, Raina K, Gupta R, Jovin TG.
    Journal: J Neuroimaging; 2008 Jan; 18(1):15-7. PubMed ID: 18190490.
    Abstract:
    We report 2 patients with angiographically demonstrated basilar artery thrombosis who received emergent intra-arterial thrombolysis with successful recanalization of the basilar artery. In the ensuing weeks after the procedure, both patients were in a locked-in state and had sustained large bilateral regions of pontine ischemia on brain imaging. Following aggressive supportive care and rehabilitation, outcomes obtained prospectively revealed that both patients made a remarkable recovery, becoming fully independent with Barthel scores of 20 and modified Rankin scores of 2.
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