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  • Title: Conjugated polyelectrolytes for label-free DNA microarrays.
    Author: He F, Feng F, Wang S.
    Journal: Trends Biotechnol; 2008 Feb; 26(2):57-9. PubMed ID: 18191257.
    Abstract:
    Classical strategies for gene microarrays require labeling of probes or target nucleic acids with signaling molecules, a process that is expensive, time consuming and not always reliable. Bazan and colleagues showed that a nucleic acid-binding cationic conjugated polyelectrolyte can be used in label-free DNA microarrays based on surfaces modified with neutral peptide nucleic acid (PNA) probes. This technique provides a simple and sensitive method for DNA detection without the need for covalent labeling of target DNA.
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