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  • Title: Urinary levels of interleukin-6 and disease activity in patients with IgA nephropathy.
    Author: Tomino Y, Funabiki K, Ohmuro H, Shimizu M, Yokoyama K, Shirato I, Shirai T, Takahashi M, Koide H.
    Journal: Am J Nephrol; 1991; 11(6):459-64. PubMed ID: 1819212.
    Abstract:
    We studied, using ELISA, 27 patients with IgA nephropathy to determine if levels of urinary interleukin-6 (IL-6) might reflect the disease activity. The levels of urinary IL-6 in patients with the advanced stage were significantly higher than those in patients with the mild stage of the disease or in healthy adults. The results showed a significant correlation between the levels of urinary IL-6 and the disease activity, i.e., levels of urinary cast and urinary protein. It was thus suggested that the measurement of urinary IL-6 is useful in evaluating the degree of glomerular injuries and/or prognosis in patients with IgA nephropathy.
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