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  • Title: Polyfunctionalized pyrrolidines by Ugi multicomponent reaction followed by palladium-mediated SN2' cyclizations.
    Author: Banfi L, Basso A, Cerulli V, Guanti G, Riva R.
    Journal: J Org Chem; 2008 Feb 15; 73(4):1608-11. PubMed ID: 18193885.
    Abstract:
    A 4-component Ugi reaction with a suitable isocyanide, followed by a novel secondary transformation involving a Pd(II)-mediated (R5 = H) or a Pd(0)-mediated (R5 = CO2Me) SN2' cyclization to give highly functionalized N-acyl-2-vinylpyrrolidines, is reported. The overall yields are usually good and in most cases the Pd(0)-catalyzed reaction gave the final product in almost quantitative yield.
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