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  • Title: A novel allele, HLA-G*010114, with a non-coding DNA base change in exon 2.
    Author: Arnaiz-Villena A, Serrano-Vela JI, Reguera R, Perez-Saborido B, Moreno E, Moscoso J.
    Journal: Tissue Antigens; 2008 Mar; 71(3):258-9. PubMed ID: 18194366.
    Abstract:
    The non-classical human leucocyte antigen (HLA) class I locus, HLA-G, shows a low protein polymorphism and a more varied DNA (eight proteins and 28 alleles). HLA-G DNA polymorphism accounts mainly for changes at third codon bases of the protein coding exons; this does not imply amino acid change in most cases. This relatively high HLA-G DNA polymorphism in comparison with their protein polymorphism suggests that evolutionary forces are acting upon HLA-G for invariance. This may be related to the immunotolerogenic function postulated for HLA-G.
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