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  • Title: MIT domainia.
    Author: Hurley JH, Yang D.
    Journal: Dev Cell; 2008 Jan; 14(1):6-8. PubMed ID: 18194647.
    Abstract:
    The AAA ATPase Vps4 disassembles the membrane-bound ESCRT-III lattice. Four recent publications show how Vps4 carries out this task in a partnership with another ESCRT-associated protein, Vta1. Vps4 and Vta1 both contain MIT domains, which bind to "MIT-interacting motifs" (MIMs) of ESCRT-III proteins. As new MIT domain proteins are rapidly being identified, these studies will likely have relevance well beyond Vps4.
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