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  • Title: The chemokine CCL5 regulates the in vivo cell surface expression of its receptor, CCR5.
    Author: Lin YL, Mettling C, Portalès P, Rouzier R, Clot J, Reynes J, Corbeau P.
    Journal: AIDS; 2008 Jan 30; 22(3):430-2. PubMed ID: 18195571.
    Abstract:
    The efficiency of CCR5 as an HIV coreceptor is strongly dependent on its level of cell surface expression. Therefore, it is of major importance to identify the factors that regulate cell surface density of CCR5. Among the chemokines that bind to CCR5, and induce its internalization, CCL5 is the most abundant in vivo. We show that the level of CCL5 production is a main factor determining CD4+ T cell surface CCR5 density.
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