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  • Title: Hypoxia, PAF, and necrotizing enterocolitis.
    Author: Caplan MS, Sun XM, Hsueh W.
    Journal: Lipids; 1991 Dec; 26(12):1340-3. PubMed ID: 1819729.
    Abstract:
    Necrotizing enterocolitis (NEC) is an important neonatal disease with a high mortality rate. The pathophysiology is unclear but epidemiologic studies suggest that hypoxia and infection are important risk factors. In this review we discuss the effect of hypoxia and platelet-activating factor (PAF) on intestinal blood flow and intestinal necrosis, and implicate PAF as an important mediator in hypoxia-induced intestinal injury. Finally we provide evidence that PAF may be important in neonatal NEC.
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