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  • Title: Platelet-activating factor may mediate dexamethasone-induced gastric damage in the rat.
    Author: Filep J, Hermán F, Braquet P.
    Journal: Lipids; 1991 Dec; 26(12):1356-8. PubMed ID: 1819733.
    Abstract:
    The possible role of platelet-activating factor (PAF) in dexamethasone-induced gastric mucosal damage was studied in rats. PAF was measured by a platelet aggregation assay. The identity of the PAF-like product recovered from gastric tissues was ascertained by thin-layer chromatography and high-pressure liquid chromatography. Low levels of PAF were detected in the normal rat stomach, while in dexamethasone-treated animals PAF levels were significantly higher. Pretreatment of the animals with BN 52021, a specific PAF receptor antagonist, significantly attenuated dexamethasone-induced mucosal injury. These findings suggest that PAF may be a mediator of mucosal damage induced by glucocorticoids.
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