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  • Title: [Electrophysiological effects of guan-fu base A on action potentials of guinea pig ventricular papillary muscles].
    Author: Zhou LM, Xu JM, Chen XH, Xie YS.
    Journal: Zhongguo Yao Li Xue Bao; 1991 Sep; 12(5):465-7. PubMed ID: 1819905.
    Abstract:
    Guan-fu base A (GA), an alkaloid first isolated in China, 50 mg.L-1 decreased the action potential amplitude and the maximal rate of depolarization (Vmax) of guinea pig papillary muscles in vitro. GA shortened the action potential period at 90% repolarization (APD90) without significant effect on the effective refractory period (ERP), resulting in an increased ERP/APD90 ratio. GA 50 mg.L-1 also slowed the conduction speed. The inhibiting effect of GA on Vmax showed frequency- and potential-dependent manners.
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