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  • Title: Pepsin behavior as a catalyst in equilibrium-controlled peptide synthesis.
    Author: Filippova IYu, Lysogorskaya EN, Anisimova VV, Abdel Malak CA, Lavrenova GI, Stepanov VM.
    Journal: Biomed Biochim Acta; 1991; 50(10-11):S98-101. PubMed ID: 1820070.
    Abstract:
    It has been shown that in the course of equilibrium peptide synthesis pepsin gradually disappeared from the liquid phase due to its entrapment within a gel formed by the hexapeptide product, while retaining its activity. The inclusion into the precipitate was not specific for pepsin so far as inert proteins-lysozyme, ribonuclease A and carbonic anhydrase, when added to the reaction mixture, became also co-precipitated with the hexapeptide formed. It appears that co-precipitation of pepsin-an important factor limiting the enzyme efficiency, might be operative as well for other proteinases used to catalyze peptide synthesis.
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