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  • Title: A case of primary Epstein-Barr virus-associated cutaneous diffuse large B-cell lymphoma unassociated with iatrogenic or endogenous immune dysregulation.
    Author: Tokuda Y, Fukushima M, Nakazawa K, Oguchi S, Koganehira Y, Yamaura M, Iijima M, Murata H, Uhara H, Takata M, Saida T, Katsuyama T, Nakamura S.
    Journal: J Cutan Pathol; 2008 Jul; 35(7):666-71. PubMed ID: 18201237.
    Abstract:
    Cutaneous Epstein-Barr virus (EBV)-associated B-cell lymphoma (EBVBL) in non-immunocompromised patients is very rare. Here, we report a case of cutaneous EBVBL in a 72-year-old Japanese woman without any signs of immunosuppression. She showed repeated high fever and skin eruptions on the face, limbs and palms. Histological diagnosis was diffuse large B-cell lymphoma. EBV infection was detected by in situ hybridization and Southern blotting. Immunostaining for viral proteins showed the patient to be positive for latent membrane protein 1 (LMP-1) and negative for Epstein-Barr virus nuclear antigen-1 (EBNA-2), indicating that a type II latency EBV infection pattern.
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