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Title: Anthocleistenolide, a new rearranged nor-secoiridoid derivative from the stem back of Anthocleista vogelii. Author: Tene M, Tane P, Kuiate JR, Tamokou Jde D, Connolly JD. Journal: Planta Med; 2008 Jan; 74(1):80-3. PubMed ID: 18203061. Abstract: A new rearranged nor-secoiridoid, anthocleistenolide ( 1), along with the known 1-hydroxy-3,7-dimethoxyxanthone ( 2), 1-hydroxy-3,7,8-trimethoxyxanthone ( 3), 7 alpha-hydroxysitosterol ( 4) and sitosterol 3- O-beta- D-glucopyranoside ( 5), were isolated from the stem back of Anthocleista vogelii. Their structures were elucidated on the basis of spectral studies and comparison with published data. Compounds 1 - 3 and 5 were evaluated for their antibacterial and antifungal activities. Relatively low anti-staphylococcal (MIC = 200 microg/mL against Staphylococcus aureus) and anti-enterococcal (MIC = 100 microg/mL against Enterococcus faecalis) activities were observed for 1, while compounds 2 and 3 were active against Candida parapsilosis (MIC = 200 microg/mL for 2 and 25 microg/mL for 3). Compound 5 was inactive against all the bacterial and fungal species used.[Abstract] [Full Text] [Related] [New Search]