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  • Title: The NPB/NPW neuropeptide system and its role in regulating energy homeostasis, pain, and emotion.
    Author: Hondo M, Ishii M, Sakurai T.
    Journal: Results Probl Cell Differ; 2008; 46():239-56. PubMed ID: 18204824.
    Abstract:
    Neuropeptide B (NPB) and neuropeptide W (NPW) are neuropeptides that were recently identified as endogenous ligands for the previously orphan G-protein coupled receptors, GPR7 (NPBWR1) and GPR8 (NPBWR2). This neuropeptide system is thought to have a role in regulating feeding behavior, energy homeostasis, neuroendocrine function, and modulating inflammatory pain. Strong and discrete expression of their receptors in the extended amygdala suggests a potential role in regulating stress responses, emotion, anxiety and fear; however, there have been no functional studies to date to support this possibility. Future studies of NPB/NPW using both pharmacological and phenotypic analysis of genetically engineered mice will lead to further elucidation of the physiological role of this novel neuropeptide system.
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