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  • Title: Cdk9/Cyclin T1 complex: a key player during the activation/differentiation process of normal lymphoid B cells.
    Author: De Falco G, Leucci E, Onnis A, Bellan C, Tigli C, Wirths S, Cerino G, Cocco M, Crupi D, De Luca A, Lanzavecchia A, Tosi P, Leoncini L, Giordano A.
    Journal: J Cell Physiol; 2008 Apr; 215(1):276-82. PubMed ID: 18205180.
    Abstract:
    Cdk9/Cyclin T1 complex is very important in controlling specific differentiative pathways of several cell types. Limited data are available regarding the expression of Cdk9/Cyclin T1 in hematopoietic and lymphoid tissues. Cdk9/Cyclin T1 expression seems to be related to particular stages of lymphoid differentiation/activation. In this study, we observed that the expression level of Cdk9/Cyclin T1 in vivo increases in memory B cells compared to naïve B cells, and in activated B cells, compared to non-activated ones. The expression level of the Cdk9/Cyclin T1 complex does not increase in cells induced to differentiate in vitro. In addition, we showed that Cdk9 interacts with E12 and E47, specifically activated during Germinal Center (GC) reaction. Taken together this data suggests an active role for the Cdk9/Cyclin T1 complex during lymphoid differentiation through germinal center reaction.
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