These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Dynamic combinatorial mass spectrometry leads to metallo-beta-lactamase inhibitors.
    Author: Liénard BM, Hüting R, Lassaux P, Galleni M, Frère JM, Schofield CJ.
    Journal: J Med Chem; 2008 Feb 14; 51(3):684-8. PubMed ID: 18205296.
    Abstract:
    The use of protein ESI mass spectrometry under non-denaturing conditions to analyze a dynamic combinatorial library of thiols/disulfides with the BcII metallo-beta-lactamase enabled the rapid identification of an inhibitor with a K(i) of < 1 microM. The study exemplifies the utility of protein-MS for screening dynamic mixtures of potential enzyme-inhibitors.
    [Abstract] [Full Text] [Related] [New Search]