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  • Title: [Effect of inorganic phosphorus on the biosynthesis of polymyxin B].
    Author: Ermakova GN, Nefelova MV, Egorov NS.
    Journal: Antibiotiki; 1976 Jul; 21(7):596-600. PubMed ID: 182070.
    Abstract:
    A synthetic medium containing optimal levels of the sources of carbon, nitrogen and inorganic phosphorus and providing satisfactory yields of polymyxin B was developed for 2 strains of Bac. polymyxa 933 and VK-153. The consumption of phosphorus in the medium by the strains and the antibiotic biosynthesis levels depended on the form of phosphorus added to the medium. Optimal biosynthesis of polymyxin B was observed at lower concentration levels of soluble soluble phosphorus in the medium than the bacterial growth.
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