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  • Title: CD117 immunoreactivity in atypical fibroxanthoma.
    Author: Mathew RA, Schlauder SM, Calder KB, Morgan MB.
    Journal: Am J Dermatopathol; 2008 Feb; 30(1):34-6. PubMed ID: 18212542.
    Abstract:
    Atypical fibroxanthoma (AFX) is a spindle cell neoplasm of the skin seen typically on sun-damaged skin of the elderly. Though described as a benign entity, local recurrence and distant metastasis have been reported. This study aims to investigate the potential pathogenic role of CD117, the c-kit receptor in AFX. CD117 was detected in 15 of the 16 cases (94%). The percentage of positive cells for CD117 expression among all tumors was approximately 30%. CD117 proved to be a very sensitive marker of AFX. This antibody may be a useful diagnostic adjunct in AFX.
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