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  • Title: [Prognosis for the development of resistance to cytostatics in leukosis cells during induction therapy in acute non-lymphoblastic leukosis: a regression model].
    Author: Popović SL.
    Journal: Med Pregl; 1991; 44(11-12):451-6. PubMed ID: 1821441.
    Abstract:
    Leucosis cell resistance to cytostatics is, apart death of a patient, the most frequent outcome of induction therapy for acute non-lymphoblastic leukosis. Aimed at the prevention and early treatment of this unwanted outcome a regression model for the prognosis of the development of the resistance was made for a group of 135 adults with acute nonlymphoblastic leukosis with 38 factors from two prognostic points: prior to and following the effects of first induction cure (time of the expected and real aplasia of the bone marrow). According to the univariant analysis, the risk for the development of the resistance depends on five pretherapeutical factors: febrility, absolute and relative neutrophilic granulocyte count in the blood, presence of monocytes and erythroblasts in the blood and all 4 factors which reconstruct the effect of the first induction cure to the bone marrow: cellularity, relative and absolute blast count and parameter S. By the multivariant analysis we distinguished 2 significant factors: parameter S used for the assessment of the selectivity level of the effects in the first induction cure to the bone marrow and the monocyte count in the blood. Early effects of the induction therapy to the bone marrow is more significantly associated with the risk for the development of the resistance than pretherapeutical factors are, while the onset of real or expected aplasia of the bone marrow is an appropriate time for the prevention and early treatment of this unwanted outcome.
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