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Title: Are elevated serum levels of IGFBP-2 after intensive chemotherapy of childhood acute lymphoblastic leukemia a risk factor of relapse? Author: Kitszel A, Krawczuk-Rybak M. Journal: Adv Med Sci; 2007; 52():147-53. PubMed ID: 18217408. Abstract: INTRODUCTION: In the study we investigated the association between IGFs, their binding proteins and pathogenesis as well as prognostic factors of relapse of childhood ALL. MATERIAL AND METHODS: In 43 children suffering from ALL, we observed 7 cases of relapse. We studied the serum levels IGF-I, IGF-II, IGFBP-3 and IGFBP-2 (expressed in SDS) in a subgroup with relapse (A) and in a subgroup without relapse (B) at diagnosis (1), after induction of remission (2) and after intensive chemotherapy (3). All comparisons were made with age-and sex-matched controls. RESULTS: It was found that in subgroup A, the values of IGFBP-2 remained high at each stage of the investigation: 3.92 +/- 2.50 (1) 3.68 +/- 0.99 (2) 3.52 +/- 1.26 (3), whereas in the subgroup B they underwent a significant reduction from 3.87 +/- 1.86 (1) 3.45 +/- 1.25 (2) 2.15 +/- 1.84 (3), p = 0.02. In comparison to a control group, the correlations between IGF-I and IGFBP-3, and IGF-1 and IGFBP-2 were disturbed for the whole group of children at each stage of the investigation. However, at diagnosis we obserwed a negative correlation between IGFBP-2 and hemoglobin (r = -0.57 p = 0.0001). CONCLUSION: Increased values of IGFBP-2 after intensive chemotherapy in children who subsequently underwent a relapse of the disease, suggest that IGFBP-2 levels might constitute a prognosis factor. However, this requires verification with a larger group of children. The negative correlation between values of hemoglobin and IGFBP-2 observed at diagnosis might further suggest the involvement of this protein in the process of leukemogenesis in children.[Abstract] [Full Text] [Related] [New Search]