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  • Title: Weight and growth requirements for menarche in teenage girls with eating disorders, weight loss and primary amenorrhea.
    Author: Swenne I.
    Journal: Horm Res; 2008; 69(3):146-51. PubMed ID: 18219217.
    Abstract:
    BACKGROUND/AIM: To investigate weight and growth requirements for menarche in girls with eating disorders (ED), weight loss and primary amenorrhea. METHODS: Growth charts from school health services and measurements of weight and stature throughout treatment were obtained for 47 such girls. RESULTS: Weight loss started at an age of 12.4 +/- 1.6 years from a top weight of 41.7 +/- 7.1 kg. Approximately a year later they had lost 5.1 +/- 4.3 kg and grown only 2.8 +/- 3.5 cm. Following treatment and weight gain, growth accelerated and the girls reached a peak growth velocity of 4.3 +/- 2.6 cm/year 2 years before menarche which occurred at an age of 15.5 +/- 1.6 years at a weight of 52.2 +/- 5.3 kg. Menarche occurred within a wide range of weights but could be predicted by a linear regression on prepubertal weight (R(2) = 0.39; p < 0.001). CONCLUSIONS: Following treatment, girls with ED and primary amenorrhea progress through puberty at a slowed rate. The weight required for menarche can be predicted by the prepubertal weight which may represent the individual's normal growth track unaffected by the ED.
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