These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Rhodanine derivatives as selective protease inhibitors against bacterial toxins.
    Author: Johnson SL, Chen LH, Harbach R, Sabet M, Savinov A, Cotton NJ, Strongin A, Guiney D, Pellecchia M.
    Journal: Chem Biol Drug Des; 2008 Feb; 71(2):131-9. PubMed ID: 18221310.
    Abstract:
    In this study, we analyzed a series of rhodanine derivatives, as potential inhibitors of bacterial toxins, namely the proteases anthrax lethal factor and the botulinum neurotoxin type A. Conducting an extensive structure-activity relationship study on rhodanine derivatives, we profiled their selectivity against the two bacterial toxins and two related human metalloproteases using in vitro assays. In addition, we examined initial in vitro ADME-Tox properties of selected compounds and their ability to protect lethal factor-induced cell death of macrophages. These data allowed the selection of one additional drug candidate for which preliminary in vivo efficacy studies against anthrax spores were conducted. Integration of these results with our structure-activity relationship studies provides a framework for the development of potential drug candidates against anthrax and botulinum.
    [Abstract] [Full Text] [Related] [New Search]