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  • Title: [The specificity in promoter recognition by the Bacillus subtilis RNA polymerase deltaA and deltaH holoenzymes is connected with periodicities in the promoter nucleotide sequences].
    Author: Kravatskaia GI, Kravatskiĭ IuV, Mil'chevskiĭ IuV, Esipova NG.
    Journal: Biofizika; 2007; 52(6):965-71. PubMed ID: 18225647.
    Abstract:
    Promoters recognized by deltaA-RNA and deltaH-RNA polymerase have different periodic patterns their nucleotide disposition. By using the special method of Fourier analysis for symbolic sequences. Fourier spectra of the primary structure of promoters transcribed bv deltaA-RNA and deltaH-RNA polymerase were obtained. For two data sets, a small one and a big one, a stepwise discriminant analysis with jackknife test based on the spectral characteristics of each of the promoters was performed. It was shown that it is possible to classify the data with the accuracy of 100% sets into classes: promoters that are recognized by the deltaA-RNA polymerise and promoters that are recognized by the deltaH-RNA polymerase. Significant correlations between the promoter strength and the characteristics of their Fourier spectra were obtained. Thus, the periodicity in nucleotide distribution along the polynucleotide chain is the attribute sufficient for promoter recognition by RNA polymerase holoenzyme.
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