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  • Title: Endoscopic submucosal dissection of recurrent or residual superficial esophageal cancer after chemoradiotherapy.
    Author: Saito Y, Takisawa H, Suzuki H, Takizawa K, Yokoi C, Nonaka S, Matsuda T, Nakanishi Y, Kato K.
    Journal: Gastrointest Endosc; 2008 Feb; 67(2):355-9. PubMed ID: 18226703.
    Abstract:
    BACKGROUND: Treatment of local recurrent or residual superficial esophageal squamous-cell carcinoma (SCC) with conventional EMR often results in a piecemeal resection that requires further intervention. OBJECTIVE: The aim of this study was to evaluate the efficacy of endoscopic submucosal dissection (ESD). DESIGN: A case series. PATIENTS: Between January 2006 and September 2006, 4 local recurrent or residual superficial esophageal SCCs were treated by ESD. INTERVENTIONS: ESD procedures were performed by using a bipolar needle knife and an insulation-tipped knife. After injection of glycerol into the submucosal (sm) layer, a circumferential incision was made, and an sm dissection was performed. All lesions were determined to be intramucosal or sm superficial, without lymph-node metastasis by EUS before treatment. MAIN OUTCOME MEASUREMENTS: Tumor size, en bloc resection rate, tumor-free lateral margin rates, and complications were recorded. RESULTS: All 4 ESD cases were successfully resected en bloc, and the tumor-free lateral margin rate was 75% (3/4) by histopathology examination. The mean tumor size of the resected specimens was 35 mm (range, 15-50 mm). There were no complications. LIMITATIONS: The number of ESDs in our series was limited, and there are no long-term follow-up data. CONCLUSIONS: ESD for recurrent or residual superficial esophageal tumors after chemoradiotherapy achieves the goal of an en bloc resection, with a low rate of incomplete treatment without any greater risk than the EMR technique.
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