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  • Title: Comparison of lipid amphotericin B preparations in treating murine zygomycosis.
    Author: Ibrahim AS, Gebremariam T, Husseiny MI, Stevens DA, Fu Y, Edwards JE, Spellberg B.
    Journal: Antimicrob Agents Chemother; 2008 Apr; 52(4):1573-6. PubMed ID: 18227182.
    Abstract:
    We compared the efficacies of liposomal amphotericin B (LAmB) and an amphotericin B lipid complex (ABLC) in diabetic ketoacidotic (DKA) or neutropenic mice with disseminated zygomycosis. ABLC was as effective as LAmB in neutropenic but not DKA mice. Low-dose ABLC was less effective than LAmB at reducing brain fungal burdens in both models.
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