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  • Title: [Recent progress in the study of HIV-1 transcription factor NF-kappaB and its inhibitors].
    Author: Yu MY, Liu XY.
    Journal: Yao Xue Xue Bao; 2007 Oct; 42(10):1007-12. PubMed ID: 18229603.
    Abstract:
    Human immunodeficiency virus type 1 (HIV-1) transcription is a crucial step in the viral replication cycle, which is considered to be a potential target for inhibition of HIV-1 replication. Among the factors involved in this step, the cellular protein nuclear factor NF-kappaB is the most powerful inducer of HIV-1 transcription. HIV-1 transcription is initiated by the binding of NF-kappaB to the enhancer region in the long terminal repeat (LTR) of HIV-1. Several compounds suppress HIV-1 transcription through the inhibition of NF-kappaB activation. The mechanisms of NF-kappaB in the transcription of HIV-1 and progress of the current inhibitors of NF-kappaB are reviewed.
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