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  • Title: Penetration of moxifloxacin and levofloxacin into cancellous and cortical bone in patients undergoing total hip arthroplasty.
    Author: Metallidis S, Topsis D, Nikolaidis J, Alexiadou E, Lazaraki G, Grovaris L, Theodoridou A, Nikolaidis P.
    Journal: J Chemother; 2007 Dec; 19(6):682-7. PubMed ID: 18230551.
    Abstract:
    Penetration of levofloxacin and moxifloxacin into cancellous and cortical bone was studied using high-performance liquid chromatography (HPLC) in 16 patients who underwent routine total hip arthroplasty. Our results demonstrate a good degree of penetration into bone for both quinolones. The mean cancellous penetration was 53.86% for moxifloxacin and 54.13% for levofloxacin. The penetration into cortical bone was 41.59% and 34.26% respectively. The concentrations for both quinolones were above the minimum inhibitory concentration (MIC(90s)) for the most common pathogens, so they can be used for the treatment of osteomyelitis.
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