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  • Title: Differences of contact photosensitivity responses to tetrachlorosalicylanilide among BALB/c, mast cell-deficient W/Wv and their normal littermate +/+ mice.
    Author: Iwamoto Y, Inoue K, Kaneko H, Shimizu T, Masuzawa T, Oku T, Yanagihara Y.
    Journal: Photodermatol Photoimmunol Photomed; 1991 Dec; 8(6):243-8. PubMed ID: 1823149.
    Abstract:
    Time course of ear swellings induced in BALB/c mice with contact photosensitivity (CPS) of tetrachlorosalicylanilide (TCSA) exhibited a typical delayed-type hypersensitivity response. Repeated challenges by the painting of TCSA and UVA irradiation on ears once a week brought about the enhancement of the early CPS response immediately after elicitation. CPS response was not induced in the mast cell-deficient mouse (W/Wv) by the standard protocol and painting in its normal littermates (+/+). However, the second challenge performed 1 week after the first challenge brought about the delayed type-like CPS response of ear swelling in both mouse strains. The early responses were enhanced stepwise by the third and fourth challenge in the normal +/+ mouse but not in the mast cell-deficient W/Wv mouse. Histological examination revealed that mast cells were not found in the any sections of ears of W/Wv mouse, whereas many mast cells were found at early stage after elicitation in the BALB/c and +/+ mice challenged 4 times. These results suggest that early responses induced by the repeated challenge in BALB/c and +/+ but not in W/Wv mice may be an immediate-type hypersensitivity.
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