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  • Title: Novel SNPs of the mtDNA ND5 gene and their associations with several growth traits in the Nanyang cattle breed.
    Author: Zhang B, Chen H, Hua L, Zhang C, Kang X, Wang X, Pan C, Lan X, Lei C.
    Journal: Biochem Genet; 2008 Jun; 46(5-6):362-8. PubMed ID: 18231850.
    Abstract:
    Polymorphism of the mtDNA ND5 gene was detected by PCR-SSCP and DNA sequencing methods in 714 individuals from six Chinese cattle breeds. The results showed that at the P2 locus, two kinds of haplotypes, named A and B, with three SNPs (T12900C, A12923T, C12924T) were detected. The frequencies of haplotype A in six breeds were 0.041-0.167. Polymorphism of the ND5 gene was shown to be associated with growth in the Nanyang breed. Individuals with haplotype B had greater hucklebone width than those with haplotype A when 6 months old (P < 0.01), as well as better body height, body length, body weight, and average daily gain at 6 months (P < 0.05). Therefore, haplotype B of the ND5 gene was likely to have a positive effect on growth traits at 6 months in the Nanyang breed.
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