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  • Title: 1,25-dihydroxyvitamin D-mediated hypercalcemia in ovarian dysgerminoma.
    Author: Hibi M, Hara F, Tomishige H, Nishida Y, Kato T, Okumura N, Hashimoto T, Kato R.
    Journal: Pediatr Hematol Oncol; 2008; 25(1):73-8. PubMed ID: 18231957.
    Abstract:
    Humoral hypercalcemia of malignancy (HHM) is a rare complication of malignant pediatric tumors, specifically those that secrete humoral factor(s), such as parathyroid hormone-related peptide (PTHrP). The authors report a case of severe hypercalcemia associated with ovarian dysgerminoma in a 10-year-old girl. In this case, the humoral factor was considered to be 1,25-dihydroxyvitamin D. HHM is extremely resistant to medical therapy. Therefore, tumor resection or volume reduction is necessary to control serum calcium levels.
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