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  • Title: [Blood exchange transfusion as an emergency treatment for hyperleukocytosis in leukemia: report of one case].
    Author: Wang CW, Lin KH, Lin YP, Chein CH, Li PJ, Ko LY.
    Journal: Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi; 1991; 32(6):387-90. PubMed ID: 1823515.
    Abstract:
    An extreme leukocytosis imposes immediate and potential catastrophic problems, which warrant the use of intensive means to reduce the excessive leukocytes. Blood exchange transfusion has been used for emergency management of hyperleukocytosis. With few complications the procedure can rapidly reduce an excessive leukocyte burden, correct concomitant anemia and improve associated metabolic abnormalities. The greatest advantage of this procedure is that it can be performed in the shortest time, with minimal equipment and technical skill. This is a report of an 11-month-old male patient with acute lymphoblastic leukemia who had hyperleukocytosis, then received emergency blood exchange which reduced the leukocyte count from 630,000/ul to 70,000/ul in two hours. The course was smooth and the patient tolerated the procedure well. Remission was attained after the induction and consolidation chemotherapy, and the child is now under maintenance therapy.
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