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  • Title: A comparative study of stimulation of erythropoiesis during renal anemia with the preparation of antibodies against erythropoietin in ultralow doses and Recormon.
    Author: Epshtein OI, Dygai AM, Zhdanov VV, Sergeeva SA, Zyuz'kov GN, Udut EV, Khrichkova TY, Simanina EV, Gur'yantseva LA, Stavrova LA, Gol'dberg ED.
    Journal: Bull Exp Biol Med; 2007 Jun; 143(6):699-702. PubMed ID: 18239805.
    Abstract:
    We compared the stimulatory effects of a preparation of antibodies against erythropoietin in ultralow doses (Poetam) and recombinant erythropoietin (Recormon) on erythropoiesis that was suppressed by carboplatin. Both drugs possessed high erythropoiesis-stimulating activity, which was manifested in an increase in the number of erythrokaryocytes and erythroid precursors in hemopoietic tissue and count of erythrokaryocytes and reticulocytes in the peripheral blood during postcytostatic recovery. Recormon produced a rapid and short-term stimulatory effect on the erythron. The effect of Poetam developed slowly, but persisted for a longer time.
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