These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Neuronal connexin expression in the cochlear nucleus of big brown bats.
    Author: Horowitz SS, Stamper SA, Simmons JA.
    Journal: Brain Res; 2008 Mar 04; 1197():76-84. PubMed ID: 18241843.
    Abstract:
    We present immunohistochemical data describing the presence and distribution of connexins, structural component of gap junctions, in the cochlear nuclei of adult big brown bats (Eptesicus fuscus). Echolocating big brown bats show microsecond scale echo-delay sensitivity that requires accurate synchronization of neuronal responses to the timing of echoes. Midbrain and auditory cortical neuronal response timing is similar to that observed in other non-echolocating mammals, suggesting that lower auditory processing nuclei may have specialized mechanisms for obtaining the required temporal hyperacuity. Our data shows that connexin 36, a gap junction protein specific to neurons, is most densely expressed in the bat's cochlear nuclear complex, the medullary region that receives and processes first-order afferents from the auditory nerve. Cx36 expression is absent in the cochlear nucleus of normal mice, which have high-frequency hearing sensitivity similar to big brown bats. Glial connexins, Cx26 and Cx43, expressed in astrocytes and several inner ear structures, are also found in the bat cochlear nucleus complex, associated with major fiber tracts in and around the cochlear nuclei. The extensive presence of neuronally-associated Cx36 in brainstem auditory structures of adult bats suggests a possible role for gap junctions in mediating echo-delay hyperacuity.
    [Abstract] [Full Text] [Related] [New Search]