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  • Title: [Prevention of early-onset group B streptococcus neonatal diseases. The 2005 experience of the Lille University Health Center].
    Author: Thibaudon Baveux C, Stroebel Noguer A, Boulard Mallet I, Djavadzadeh-Amini M, Kacet N, Truffert P, Subtil D, Dubos JP.
    Journal: J Gynecol Obstet Biol Reprod (Paris); 2008 Jun; 37(4):392-9. PubMed ID: 18243572.
    Abstract:
    OBJECTIVES: To study the efficiency of the official recommendations on the prevention of group B streptococcus and the impact of this strategy. MATERIALS AND METHODS: A prospective study was realized in 2005. All infants who were live-born at the Jeanne-de-Flandre hospital (Lille, France) and their mothers were included in the study. Data concerned both pregnancy (vaginal screening, intrapartum antibiotic) and newborn (safe, colonization and early-onset neonatal bacterial disease). RESULTS: Our study included 4353 mother-newborn couples. Vaginal screening was performed on 92% of the women included in the study. Prevalence of vaginal group B streptococcus in screened women was 7%. Perpartum antibioprophylaxia of group B streptococcus was achieved in 12% of the women included in the study. Group B streptococcus was associated to 60% of probable and certain early-onset bacterial neonatal diseases, with an incidence of 9/1000 births. Exposition to antenatal antibiotherapy multiplied by two the risk of ampicillin resistant Gram-negative bacilli (RR=2 [1.1-3.8]). CONCLUSION: Recommendations were well followed, but in our health center group, B streptococcus was the main bacteria responsible for early-onset bacterial neonatal diseases. Because of the risk of germ selection, a more targeted antibioprophylaxia has to be preferred.
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