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  • Title: Thiosemicarbazones active against Clostridium difficile.
    Author: Costello C, Karpanen T, Lambert PA, Mistry P, Parker KJ, Rathbone DL, Ren J, Wheeldon L, Worthington T.
    Journal: Bioorg Med Chem Lett; 2008 Mar 01; 18(5):1708-11. PubMed ID: 18243694.
    Abstract:
    A set of closely related furylidene thiosemicarbazones was prepared and screened against various clinically important Gram-positive bacteria. One compound containing an ethylene spacer and a 5-nitrofuryl group was found to have promising activity against Clostridium difficile.
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