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  • Title: Expression of CD4 in transgenic mice alters the specificity of CD8 cells for allogeneic major histocompatibility complex.
    Author: Robey E, Ramsdell F, Elliott J, Raulet D, Kioussis D, Axel R, Fowlkes BJ.
    Journal: Proc Natl Acad Sci U S A; 1991 Jan 15; 88(2):608-12. PubMed ID: 1824875.
    Abstract:
    We have generated a transgenic mouse line in which a CD4 transgene is expressed on a significant fraction of the mature CD8+ lymphocytes but is not expressed in the thymus. This provides an opportunity to examine the functional consequences of CD4 expression in a population of class I-selected CD8+ lymphocytes. CD8+ lymphocytes expressing the CD4 transgene proliferate in response to allogeneic class I and class II major histocompatibility complex, whereas CD8+ cells from control animals proliferate only to allogeneic class I gene products. These observations suggest that the ability of a T-cell population to react with class II allogeneic major histocompatibility complex is determined by the presence of CD4.
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