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  • Title: Entry into a new class of protein kinase inhibitors by pseudo ring design.
    Author: Furet P, Caravatti G, Guagnano V, Lang M, Meyer T, Schoepfer J.
    Journal: Bioorg Med Chem Lett; 2008 Feb 01; 18(3):897-900. PubMed ID: 18248988.
    Abstract:
    A pyrimidin-4-yl-urea motif forming a pseudo ring by intramolecular hydrogen bonding has been designed to mimic the pyrido[2,3-d]pyrimidin-7-one core structure of a well-established class of protein kinase inhibitors. Potent inhibition of a number of protein kinases was obtained with the first prototype compound synthesized to probe the design concept.
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