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  • Title: Synthesis, thermal stability, antimalarial activity of symmetrically and asymmetrically substituted tetraoxanes.
    Author: Atheaya H, Khan SI, Mamgain R, Rawat DS.
    Journal: Bioorg Med Chem Lett; 2008 Feb 15; 18(4):1446-9. PubMed ID: 18248990.
    Abstract:
    Symmetrically and asymmetrically substituted 1,2,4,5-tetraoxanes were synthesized by the oxidative system H(2)O(2)/TFE in presence of MeReO(3) as a catalyst. All of the synthesized compounds were characterized spectroscopically, and evaluated for cytotoxicity, and antimalarial activity. Several of these tetraoxanes exhibited in vitro antimalarial activity without showing any cytotoxicity. Thermal stability of these compounds was studied by differential scanning calorimetry.
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