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  • Title: Contribution of spinal MRI for unsuspected cobalamin deficiency in isolated sub-acute combined degeneration.
    Author: Maamar M, Mezalek ZT, Harmouche H, Adnaoui M, Aouni M, Maaouni A.
    Journal: Eur J Intern Med; 2008 Mar; 19(2):143-5. PubMed ID: 18249313.
    Abstract:
    Sub-acute combined degeneration (SCD) is a rare cause of demyelination of the dorsal and lateral columns of the spinal cord and is a neurological complication due to vitamin B12 deficiency. Revealing forms of SCD without anemia are rare. We report a case of SCD of the spinal cord in a 33-year-old woman without anemia but with a 10-month history of paresthesis and urine imperiosity. Magnetic resonance imaging (MRI) of the spine showed intramedullary hyperintensity seen on T2-weighted images in the posterior column of the cervico-dorsal spinal cord, extending from C1 to D1. A diagnosis of SCD of the spinal cord was considered and confirmed by a low serum cobalamin. The patient was treated with vitamin B12 supplements and showed gradual improvement in her clinical symptoms.
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