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  • Title: Guillain-Barré syndrome after treatment with sunitinib malate?
    Author: Mulherin B, Loconte NK, Holen KD.
    Journal: Oncology (Williston Park); 2008 Jan; 22(1):66-7, 70-1. PubMed ID: 18251284.
    Abstract:
    Sunitinib malate (Sutent, SU011248) is an oral multitargeted tyrosine kinase inhibitor used for treatment of renal cell carcinoma and gastrointestinal stromal tumor. We report a case of a patient who developed Guillain-Barrd syndrome after initial treatment with sunitinib, with recurrent symptoms upon reintroducing the drug. This is the first report of such an effect. The literature on chemotherapy-induced Guillain-Barri syndrome is also reviewed. Oncology providers should be aware of this rare but potentially serious possible adverse effect of sunitinib.
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