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  • Title: Mature adipocytes may be a source of stem cells for tissue engineering.
    Author: Fernyhough ME, Hausman GJ, Guan LL, Okine E, Moore SS, Dodson MV.
    Journal: Biochem Biophys Res Commun; 2008 Apr 11; 368(3):455-7. PubMed ID: 18252194.
    Abstract:
    Adipose tissue contains a large portion of stem cells. These cells appear morphologically like fibroblasts and are primarily derived from the stromal cell fraction. Mature (lipid-filled) adipocytes possess the ability to become proliferative cells and have been shown to produce progeny cells that possess the same morphological (fibroblast-like) appearance as the stem cells from the stromal fraction. A closer examination of mature adipocyte-derived progeny cells may prove to be an emerging area of growth/metabolic physiology that may modify present thinking about adipose tissue renewal capabilities. Knowledge of these cells may also prove beneficial in cell-based therapies for tissue repair, regeneration, or engineering.
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