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  • Title: HER-2/neu targeting for recurrent vulvar Paget's disease A case report and literature review.
    Author: Karam A, Berek JS, Stenson A, Rao J, Dorigo O.
    Journal: Gynecol Oncol; 2008 Dec; 111(3):568-71. PubMed ID: 18252264.
    Abstract:
    BACKGROUND: The treatment of Paget's disease of the vulva particularly for recurrences can be challenging. Overexpression of the HER-2/neu protein has been found in about 30% of vulvar Paget's cases therefore presenting a potential therapeutic target. CASE: We report the case of a 52-year-old patient with persistent Paget's disease of the vulva despite eight surgical excisions over a 15-year period. Immunohistochemistry demonstrated overexpression of the HER-2/neu protein in the vulva resection specimen. Treatment with Trastuzumab resulted in a significant regression of her disease and resolution of symptoms. CONCLUSION: Based on our case report, therapeutic targeting of HER-2/neu for patients with Paget's disease of the vulva using for example Trastuzumab is a potentially effective, alternative approach, and warrants further investigation.
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