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  • Title: Synthesis and antiplasmodial activity of 3-furyl and 3-thienylquinoxaline-2-carbonitrile 1,4-di-N-oxide derivatives.
    Author: Vicente E, Charnaud S, Bongard E, Villar R, Burguete A, Solano B, Ancizu S, Pérez-Silanes S, Aldana I, Vivas L, Monge A.
    Journal: Molecules; 2008 Jan 17; 13(1):69-77. PubMed ID: 18259130.
    Abstract:
    The aim of this study was to identify new compounds active against Plasmodium falciparum based on our previous research carried out on 3-phenyl-quinoxaline-2-carbonitrile 1,4-di-N-oxide derivatives. Twelve compounds were synthesized and evaluated for antimalarial activity. Eight of them showed an IC(50) less than 1 microM against the 3D7 strain. Derivative 1 demonstrated high potency (IC(50)= 0.63 microM) and good selectivity (SI=10.35), thereby becoming a new lead-compound.
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