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  • Title: Antiplatelet aggregation coumarins from the leaves of Murraya omphalocarpa.
    Author: Chia YC, Chang FR, Wang JC, Wu CC, Chiang MY, Lan YH, Chen KS, Wu YC.
    Journal: Molecules; 2008 Jan 21; 13(1):122-8. PubMed ID: 18259135.
    Abstract:
    Using a bioactivity-guided fractionation method, two coumarins: minumicroline acetonide (1) and epimurpaniculol senecioate (2), were isolated from the leaves of Murraya omphalocarpa Hayata (Rutaceae). Compound 1 had been previously synthesized and was now isolated from natural sources for the first time, and compound 2, possessing a negative optical rotation value, is new. The structures and their stereochemistry were fully elucidated on the basis of spectroscopic and X-ray crystallographic techniques. Both compounds 1 and 2 are active in the antiplatelet aggregation assay. Interestingly, the possible acetonide artifact 1 displayed significant antiplatelet aggregation induced not only by AA and collagen but also by platelet activating factor (PAF).
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